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| Links: Microbiology |
| Biological Weapons |
Genetically-modified BWs especially - is a very frightening perspective .. "As it is possible to place multiple virulence/toxic capacities within a single organism or to fuse two toxic proteins together so that both would be functional "
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| Date Added: 14.12.06 |
Visits: 1664 |
| Chronic bacterial infections: living with unwanted guests. |
Young D, Hussell T, Dougan G. Nat Immunol. 2002 Nov;3(11):1026-32.
Some bacterial pathogens can establish life-long chronic infections in their hosts. Persistence is normally established after an acute infection period involving activation of both the innate and acquired immune systems. Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection. ….
(PDF can be downloaded after free registration)
"... Antigenic variation is also a strategy used by several bacterial pathogens to evade the humoral immune syste and persist in the host. Some bacteria such as Borrelia burgdorferi ... encode sophisticated genetic systems and gene families to increase the diversity of surface-located proteins in a similar manner to eukaryotic trypanosomes." |
| Date Added: 14.12.06 |
Visits: 2519 |
| Bilogical Warfare |
| Biological warfare, also known as germ warfare, is the use of any pathogen (bacteria, virus or other disease-causing organism) or toxin found in nature, as a weapon of war. |
| Date Added: 14.12.06 |
Visits: 1627 |
| Germ Warfare - The Hall of Shame |
Chemical-Biological Warfare - history
The United States has a long history of experimentation, on unwitting human subjects, which goes back to the beginning of this century. Both private firms and the military have used unknowing human populations to test various theories. However, the extent to which human experimentation has been a part of the U.S. Biological Weapons programs will probably never be known. The following examples are taken from information declassified in 1977, and from other private source accounts. ... |
| Date Added: 14.12.06 |
Visits: 1607 |
| Tuskegee Syphilis Study |
(Google) Citation from Wiki: "By 1947, penicillin had become standard treatment for syphilis. Prior to this discovery, syphilis frequently led to a chronic, painful and fatal multisystem disease. Rather than treat all syphilitic subjects with penicillin and close the study, the Tuskegee scientists withheld penicillin or information about penicillin purely to continue to study how the disease spreads and kills. Participants were also prevented from accessing syphilis treatment programs that were available to other people in the area. The study continued until 1972, when a leak to the press -- rather than any ethical or moral consideration -- resulted in its termination. The Tuskegee Syphilis Study is often cited as one of the greatest ethical breaches of trust between physician and patients in the setting of a clinical study in the United States."
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| Date Added: 14.12.06 |
Visits: 1587 |
| Hostile takeovers: viral appropriation of the NF-kB pathway |
Hiscott J et al. Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest 2001 Jan;107(2):143-51. Several other parasitic intracellular infections seem to do the same trick. Rickettsia rickettsii, Theileria both prevent apoptosis by NF-kappaB activation and B.burgdorferi, Treponema pallidum to mention just a few other bacteria also activates NF-kappaB. Possible co-work between virus and bacteria here - that promote development of chronic infection ??
(full text, including link to PDF-download)
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| Date Added: 14.12.06 |
Visits: 2056 |
| NFkB |
| Marie Kroun ... (working on) a review on NFkB / microbial take over .... |
| Date Added: 14.12.06 |
Visits: 1415 |
| HHV6 - Humane Herpes Virus 6 |
by Joseph H. Brewer, M.D.
Human herpesvirus-6 was discovered in 1986. Since then, a considerable amount of research information has been published regarding this fascinating virus. The role of this relatively new member of the herpes family in human disease continues to be defined. It is now widely accepted that primary infection results in roseola (erythema subitum). The virus can also cause a mononucleosis-like syndrome in older children and adults. HHV-6 has now been associated with a variety of potentially life-threatening infectious complications in the immune compromised host. Numerous serious neurologic conditions have been described in both the normal host (children and adults), and the immune compromised host. The virus is clearly neurotropic and immunotropic. Recent evidence also suggests tropism and infection of endothelial cells. ....
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| Date Added: 14.12.06 |
Visits: 1517 |
| Medical Microbiology 4th. ed. |
Samuel Baron, MD. University of Texas Medical Branch - chapters on leptospira, borrelia and spirillum, rickettsia etc.
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| Date Added: 14.12.06 |
Visits: 1449 |
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