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Links: Piroplasma & other "ringforms"
Babesiosis as an underlying factor .. perianal fistulas ...
Babesiosis as an underlying factor influencing the severity and duration of perianal fistulas in three dogs.
Tarello W. Revue de Medecine Veterinaire, 152, 1, 83-88 (2001). Abstract: Perianal fistulas is a serious problem mostly affecting German shepherd dogs, which are predisposed to this condition as a result of breed and anatomical factors. A decreased cell-mediated immune response and similarities with the fistulous form of Crohn's disease in humans have been recently noted. Consequently, a thorough search for the underlying factors seems advisable as part of the diagnostic work, with a view to the possibility of treatment by chemotherapy. The two 3-year old German shepherds and one 14-year old Pomeranian dog with perianal fistulas, described in the present report were found to be carriers of Babesia spp. without specific clinical symptoms and signs of babesiosis, and consequently treated with imidocarb dipropionate once a week for 4 weeks. This therapy led to a complete recovery from the perianal fistulas, without subsequent relapses no surgery was needed.
Date Added: 16.12.06 Visits: 592
Babesiosis in Upstate NY ...
Babesiosis in Upstate NY: PCR and RNA Evidence of Co-Infection with Babesica microti Among Ixodidae Ticks in Dutchess County, NY
Richard Horowitz
Date Added: 16.12.06 Visits: 604
Babesiosis in Washington State: a new species of Babesia?
Quick RE et al. Ann Intern Med 1993 Aug 15;119(4):284-90. " serum had very strong IFA reactivity with WA1, strong reactivity with B. gibsoni (which infects dogs), but only weak reactivity with B. microti. ..WA1 is morphologically indistinguishable but antigenically and genotypically distinct from B. microti."
Date Added: 16.12.06 Visits: 695
Transfusion-associated babesiosis after heart transplant
Lux JZ, Weiss D, Linden JV, Kessler D, Herwaldt BL, Wong SJ, Keithly J, Della-Latta P, Scully BE. Emerg Infect Dis. 2003 Jan;9(1):116-9. PMID: 12533293
We describe a 54-year-old spleen-intact man with transfusion-associated Babesia microti infection after a heart transplant. Adult respiratory distress syndrome developed in the patient, and he required mechanical ventilation. Our experiences with this patient suggest that babesiosis should be considered in the differential diagnosis of transplant patients who have fever and hemolytic anemia. PDF
Date Added: 16.12.06 Visits: 712
Babesiosis in a renal transplant recipient acquired through blood transfusion
Perdrizet GA et al. Transplantation. 2000 Jul 15;70(1):205-8.
A recipient of a living-related renal transplant developed acute postoperative hemolytic anemia. The etiology of this anemia was diagnosed by peripheral red blood cell smear as Babesia microti. The patient was managed by a reduction in transplant immunosuppressive therapy and administration of clindamycin and quinine antimicrobials.
Date Added: 16.12.06 Visits: 780
Babesiosis in patients with AIDS: a chronic infection presenting as fever of unknown origin
Falagas ME, Klempner MS. Clin Infect Dis. 1996 May;22(5):809-12. "We report a case of babesiosis in a patient infected with HIV who presented with a prolonged fever of unknown origin; the patient had not undergone splenectomy. Parasitemia persisted despite initial clinical improvement after treatment with quinine and clindamycin. Babesiosis was controlled with a maintenance regimen consisting of clindamycin, doxycycline, and high-dose azithromycin, but the infection was not eradicated."
Date Added: 16.12.06 Visits: 798
Babesiosis (Homer)
Homer MJ et al. Clin Microbiol Rev 2000 Jul;13(3):451-69. Excellent review. Chart over babesia life cycle in tick and mammal host. PDF
Date Added: 16.12.06 Visits: 883
Babesiosis. Diagnostic pitfalls
Carr JM et al. Am J Clin Pathol. 1991 Jun;95(6):774-7. "A case of babesiosis complicated by quinine-induced hemolysis is described. A splenectomized woman contracted babesiosis after visiting an endemic area. The patient presented with high fevers and minimal hemolysis. While she was on treatment, the hemolysis increased. The increased hemolysis was initially attributed to babesiosis, but after additional evaluation quinine therapy was found to be the cause."
Date Added: 16.12.06 Visits: 694
Babesiosis: An Update on Epidemiology and Treatment

Gelfand JA, Callahan MV. Curr Infect Dis Rep. 2003 Feb;5(1):53-58. "North American cases are treated either with quinine and clindamycin or with atovaquone and azithromycin. The latter regimen appears less toxic."
Date Added: 16.12.06 Visits: 797
Babesiosis: an underdiagnosed disease of children
Krause PJ et al. Pediatrics. 1992 Jun;89(6 Pt 1):1045-8. "To determine whether children are infected with B microti less often than are adults, a prospective serosurvey was carried out on Block Island, RI, where babesiosis is endemic. Randomly recruited subjects completed a questionnaire and provided a blood sample. Antibodies against B microti and B burgdorferi were measured using a standard indirect immunofluorescence assay and enzyme-linked immunosorbent assay, respectively. Of 574 subjects, 9% tested positive for B microti, including 12% of the 52 children (7 months through 16 years) and 8% of the 522 adults (not significant, P less than .6). Although babesiosis had not been diagnosed in any of the Babesia-seropositive subjects, 25% of the children and 20% of the adults reported symptoms compatible with this infection during the previous year. Of the 6 children and 45 adults seropositive for B burgdorferi, 17% and 14%, respectively, were also seropositive for B microti. "
Date Added: 16.12.06 Visits: 682
When to Suspect and How to Monitor Babesiosis
Mylonakis E. Am. Fam. Phys. 2001; 63(10): 1969-1974 PDF
Date Added: 16.12.06 Visits: 764
Human babesiosis: report of a case with fatal outcome
Calvo de Mora A et al. Med Clin (Barc). 1985 Oct 19;85(12):515-6.
Date Added: 16.12.06 Visits: 742
Human babesiosis: first case report in Switzerland
Loutan L et al. Rev Med Suisse Romande. 1994 Feb;114(2):111-6.
Date Added: 16.12.06 Visits: 712
First documentation of transfusion-associated babesiosis in Japan
Matsui T et al. Rinsho Ketsueki. 2000 Aug;41(8):628-34. "To investigate the cause of the hemolysis, the patient was transferred to our hospital in May 1999. Giemsa-stained peripheral blood smears showed Babesia parasites in the red blood cells (RBC), and PCR analysis confirmed the presence of Babesia microti DNA. The parasitemia disappeared hematologically after 2 weeks of quinine and clindamycin therapy. However, parasite DNA was still detectable in the RBC. Although treatment with oral atovaquone was given for 2 weeks, parasitemia and febrile hemolysis recurred within a month after the last treatment. Fortunately, complete remission was obtained after a second 12-week course of therapy with quinine and clindamycin. PCR analysis revealed asymptomatic Babesia infection in one of eight samples from the original blood donor. The initial steroid therapy given to the patient without an accurate diagnosis seemed to have delayed augmentation of the specific antibodies (IgG) against Babesia microti, thus prolonging the parasitemia after the initial acute stage of babesiosis."
Date Added: 16.12.06 Visits: 706
Babesiosis (danish)
Jensen K. Ugeskr Laeger. 1998 Aug 24;160(35):5065.
Date Added: 16.12.06 Visits: 728
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